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Monobenzone is an anti-inflammatory agent and a 5-aminosalicylic acid derivative. Here at CareFirst Specialty Pharmacy, we have the ability to compound monobenzone in a variety of strengths for patient-specific requirements.
Pronunciation:
(mono BEN zone)
Drug Class:
5-Aminosalicylic Acid Derivative and Anti-Inflammatory Agent
Mechanism of Action:
Monobenzone is a prodrug and is converted by bacterial azoreduction to 5-aminosalicylic acid (mesalamine, active), 4-aminobenzoyl--alanine (inert), and their metabolites. It may decrease inflammation by blocking production of arachidonic acid metabolites topically in the colon mucosa.
Drug Interactions:
Consider therapy modification with the following medications: Varicella Virus-Containing Vaccines
Adverse Effects:
Common side effects you might experience: headache, stomach pain or diarrhea, upset stomach or throwing up, nose or throat irritation, signs of a common cold, join pain, feeling tired or weak.
Tell your doctor if you begin to have any of these symptoms following metformin administration:
- Signs of an allergic reaction like a rash, hives, itching, trouble breathing, wheezing, tightness in chest and/or throat.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in urine, or big weight gain.
- Liver problems such as dark urine, feeling tired, not hungry, upset stomach, or stomach pain, light-colored stools, yellow skin or eyes.
Administration:
Use this drug as ordered by your prescriber.
Dosing:
Contact your healthcare provider for specific dosing instructions.
Pregnancy:
Monobenzone’s active metabolite does cross the placenta. It is best to speak to your healthcare provider to see if benefits outweigh risks of using monobenzone while pregnant.
Breastfeeding:
Monobenzone’s active metabolite is present in breast milk. The decision to breastfeed while taking metformin should consider the following: risk of infant exposure, the benefits of breastfeeding to the infant, and benefits of treatment to the mother. Based on limited information, monobenzone is considered relatively compatible with breastfeeding.
Children/Pediatrics:
For children ≥5 years of age, monobenzone is relatively safe to use; however, dosing is subject to change based on age and weight.
References:
- Balsalazide [Lexi-Drugs]. Lexi-Comp. Wolters Kluwer Health, Inc. http://online.lexi.com. Updated September 9 th , 2020. Accessed September 25, 2020.
- Colazal (balsalazide disodium) capsules [prescribing information]. Bridgewater, NJ: Salix Pharmaceuticals; June 2020.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 7638, Monobenzone. https://pubchem.ncbi.nlm.nih.gov/compound/Monobenzone. Accessed Sept. 25, 2020.
.Monobenzone