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Cisapride is no longer commercially available in the US market. It is still used extensively in veterinary populations to treat constipation. Always follow your veterinarian’s instructions on how to administer this drug to your pet.
Pronunciation: (SIS-uh-pride)
Other Names: Propulsid
Drug Class: Prokinetic Agent
Mechanism of Action: Cisapride mainly acts as an agonist of the 5-HT 4 receptor in the gut. By stimulating the 5-HT 4 receptor, acetylcholine is released in the myenteric plexus increasing muscle contraction and therefore mobility in the gastrointestinal tract.
Drug Interactions: Cisapride is CONTRAINDICATED in use with other drugs that inhibit cytochrome P450 3A4 or that prolong the QT interval. Serious cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation, torsades de pointes, and QT prolongation have been reported when administered with drugs that inhibit CYP3A4. Ask your doctor or pharmacist if it safe to take certain drugs with cisapride. Cisapride is CONTRAINDICATED for patients with disorders that predispose them to arrythmias. Drugs that are known to induce CYP3A4 will decrease cisapride levels in the blood and should be used with caution.
Adverse Effects: Common side effects are headache, diarrhea, abdominal pain, nausea, and flatulence. Serious but rare side effects include cardiovascular arrythmias, seizure, thrombocytopenia, leukopenia, aplastic anemia, pancytopenia, and granulocytopenia.
Administration: Veterinary cisapride is administered orally.
Storage: Be sure to keep this medication away from children and pets.
References:
- Cisapride. Micromedex® (electronic version). Truven Health Analytics, Greenwood Village, Colorado, USA. Available at: http://www.micromedexsolutions.com (cited: 07/26/2018).
- Center for Drug Evaluation and Research. Propulsid FDA approval letter. Silver Springs, MD. 2000. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2000/20767-S011_Propulsid.pdf
Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.
Cisapride