Proflora 4R is a unique spore-forming (soil-based) probiotic with additional botanicals to support microbial balance and GI health.* The combination of quercetin, marshmallow root, and aloe vera extract in Proflora 4R provide additional nutritional support for healthy microbial balance, with just one capsule per day, preferably at bedtime. Spore-forming probiotics are commensal bacteria found in our gastrointestinal tract. Unlike conventional probiotics, Proflora 4R does not require refrigeration, and is designed to survive stomach acid.